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Automation in the Life Science Research Laboratory

Protocols in the academic life science laboratory are heavily reliant on the manual manipulation of tools, reagents and instruments by a host of research staff and students. In contrast to industrial and clinical laboratory environments, the usage of automation to augment or replace manual tasks is limited. Causes of this… Read More

Automated 3D Microphysiometry Facilitates High-Content And Highly Reproducible Oxygen Measurements Within 3D Cell Culture Models

Microphysiometry is a powerful technique to study metabolic parameters and detect changes to external stimuli. However, applying this technique for automated label-free and real-time measurements within cell-laden three-dimensional (3D) cell culture constructs remains a challenge. Read More

Catalyzing rapid discovery of gold-precipitating bacterial lineages with university students

Intriguing and potentially commercially useful microorganisms are found in our surroundings and new tools allow us to learn about their genetic potential and evolutionary history. Engaging students from different disciplines and courses in the search for microbes requires an exciting project with innovative but straightforward procedures and goals. … Read More

Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts

Despite antibiotics and sterile technique, postoperative infections remain a real and present danger to patients. Read More

Automation of three ELISA protocols on the Opentrons OT-2 with an on-deck Heater-Shaker Module

Enzyme immunoassays (EIAs) or enzyme-linked immunosorbent assays (ELISAs) are widely used analytic tools for detection of a target molecule (e.g., an antigen) in liquid samples for diagnostic or research purposes. Read More

An Open-Source Shipping Container Laboratory Optimised For Automated COVID-19 Diagnostics

The COVID-19 pandemic has challenged diagnostic systems globally. Expanding testing capabilities to conduct population-wide screening for COVID-19 requires innovation in diagnostic services at both the molecular and industrial scale. No report to-date has considered the complexity of laboratory infrastructure in conjunction with the available molecular assays to offer a standardised… Read More

An Affordable Open-Source Robotic Platform For SARS-CoV-2 Testing By RT-qPCR

Current global pandemic due to the SARS-CoV-2 has struggled and pushed the limits of global health systems. Supply chain disruptions and scarce availability of commercial laboratory reagents have motivated worldwide actors to search for alternative workflows to cope with the demand. Read More

Rapid Emergence and Epidemiologic Characteristics of the SARS-CoV-2 B.1.526 Variant

Rapid integration of whole genome sequencing and population-based surveillance data is critical to characterizing new SARS-CoV-2 variants. Read More

Implementation Of An Efficient SARS-CoV-2 Specimen Pooling Strategy For High Throughput Diagnostic Testing

Two automatable in-house protocols for high-troughput RNA extraction from nasopharyngeal swabs for SARS-CoV-2 detection have been evaluated. Read More

Evaluation Of Two Automated Low-Cost RNA Extraction Protocols For SARS-CoV-2 Detection

Two automatable in-house protocols for high-troughput RNA extraction from nasopharyngeal swabs for SARS-CoV-2 detection have been evaluated. Read More